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What may be the best way to take CBD part 2!

CBD sublingual bioavailability

When administered sublingually (via drops held beneath the tongue), CBD oil has a sublingual bioavailability of 13% to 19%, with some studies putting it as high as 35%. Holding the CBD beneath your tongue allows it to be absorbed by your sublingual gland, through which it can enter the bloodstream and begin working its effects. While not quite as expedient as the inhalation method, sublingual administration of CBD still produces effects fairly quickly, within 20 minutes or so.

Of course, the trick here is to hold the CBD in the appropriate place (beneath the tongue) for an appropriate amount of time (30 to 60 seconds). If you swallow too soon, or apply the drops above your tongue and swallow quickly, you may as well be taking the CBD orally—which, as we’ll review in the next section, offers significantly lower bioavailability.

Sublingual Bioavailability of CBD

Product ExamplesBioavailability RateCBD tinctures CBD sprays13% to 19%, up to 35%

Effects felt within 5 to 20 minutes


CBD oral bioavailability

Oral ingestion is popular because it’s a method people are already familiar with, from eating food, drinking beverages, and swallowing daily vitamin. Unfortunately, while oral ingestion may be common, it’s also the least effective method for taking CBD. The oral bioavailability of CBD is between 10% to 20%, although some studies have found it to be as low as 6%.

Why is CBD’s oral bioavailability so low? When you consume CBD orally, it must pass through your digestive system first, before it ever reaches your bloodstream. This process is not a quick one—taking up to 2 hours for some people—and during it, some of the CBD gets lost to the liver and digestive tract. As a result, you’ll have to wait longer for the CBD to provide relief, and the relief it does provide may not be as effective (since so much was lost during the journey).

Oral Bioavailability of CBD

Product ExamplesBioavailability RateCBD edibles, like chocolate or baked goods CBD concentrate added to water or food CBD capsules CBD gummies6% to 20% Effects felt within 30 to 120 minutes

CBD topical bioavailability

With all three of the above methods, you consumed the CBD through your mouth. There is one alternate way to take CBD—topically through the skin. With this method, CBD engages primarily with the endocannabinoid receptors located in your peripheral nervous system—so, it’s best for providing targeted pain relief in a particular area, such as arthritic joints or sore muscles. 

Because the CBD only interacts with local receptors in your skin, though, it won’t enter the bloodstream. As a result, topical administration will be ineffective for relieving conditions which require the CBD to bind to cannabinoid receptors in the brain and central nervous system, such as anxiety, epilepsy, or PTSD.

As with sublingual administration, topical administration requires the user to be aware of the correct method of application in order to experience the maximum benefits. While you do have pores in your skin, generally the skin is not very porous. It’s built to be a barrier that protects our internal organs from the outside world, after all. In order to bypass this protection, you need to apply CBD topicals liberally and vigorously into the targeted area, in order to ensure the CBD actually gets absorbed. 

The bioavailability of topical CBD hasn’t been quantified, although it’s expected to be low. Even so, multiple studies, including this one using purified CBD cream to treat MS-related limb paralysis, have found topical CBD to be effective at providing pain relief.

Some CBD brands have created innovative products that address topical CBD’s problem of lower bioavailability. For instance, transdermal patches, like those sold by MedicalMary, enable the CBD to cross through the skin and enter the bloodstream. According to one study of arthritic rats, transdermal patches significantly relieve pain and inflammation in the knee joint. 

CBD suppositories, like those sold by Endoca CBD, may also increase the bioavailability of CBD, allowing it to enter the bloodstream via membranes in the anus or vagina. One study found that rectal application can be 25% to 50% more effective than oral administration, providing an average bioavailability of 13.5%.

Topical Bioavailability of CBD

Product ExamplesBioavailability RateCBD salves CBD creams and lotions CBD serum CBD lip balms CBD transdermal patches CBD suppositoriesLow, although higher with transdermal or rectal

Effects felt within minutes

Can you increase the bioavailability of CBD?

You can’t really increase the bioavailability of CBD. What you can do, however, is optimize your method of administration to ensure you receive your ideal dose of CBD.

Keep in mind that all of the bioavailabilities listed above were achieved by expert researchers trained in administering the kind of hyper-precise doses required in scientific study. Your experience administering CBD to yourself may vary. But, you can still use these as a guide.

When taking CBD products at home, try multiplying the bioavailability rate by the amount of CBD in a serving size. The result of this calculation is closer to the “true” dose you’ll receive. Once you know the “true” dose, you can adjust your serving size accordingly. For example:

A 1500mg tincture, where a full 1ml dropper provides a serving size of 50mg of CBD, may actually deliver 6mg to 17.5mg of CBD. A 300mg pre-filled vape cartridge, if smoked all at once, may deliver a dose of 102mg to 138mg of CBD.

If you’re using CBD topicals, remember that their bioavailability is quite low, so you may have to experiment to find an effective dose. By their nature, dosing with CBD topicals is imprecise. Most brands will direct you with vague instructions like “apply a finger-sized amount” or “use liberally. Follow their instructions, but also be aware that you may require a higher-dose product than you expect, simply because it’s harder for the CBD to break through the skin.

When it comes down to it you will just have to test CBD and see what works best for you. We offer all forms of CBD and have samples available. Thanks for support to find more info and data stop by cbdoil.org for the full report and story.

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